Anadenanthera colubrina, is also known as Yopo, cebil, Vilca. Archaeological remains of Anadenanthera colubrina have been found all throughout South America and the West Indies.

The two species of trees in the Anadenanthera genus (A. peregrina and A. colubrina) both have similar salvia properties and have been widely used in American Indian cultures.

Anadenanthera is one of the four most widely used types of substance in traditional South American Indian cultures, along with tobacco, Ayahuasca and Virola species.

The antiquity of Anadenanthera use has been confirmed by important archaeological discoveries.